New York, NY, United States, 10/20/2021 / Top Wire News /
It’s now common knowledge that Obesity can impact a person’s heart, joints, gut, blood sugar levels, and liver, among other things. Now you have another reason to lose extra weight as obesity also has a direct impact on your hair density.
As reported by ANI, a new study found that obesity can lead to hair thinning and hair loss. The Study’s findings were published in the journal Nature and shed light on the complicated link between obesity and organ dysfunction. The study was conducted by researchers from Tokyo Medical and Dental University and used mouse model experiments to find out how a high-fat diet or genetically induced obesity affects hair loss and hair thinning.
The researchers found that stem cells within hair follicles in mice that were given a high-fat diet behaved differently than the stem cells within hair follicles in mice that were given a standard diet. “Inflammatory signals in the stem cells led to these differences, ultimately resulting in hair thinning and loss. These fascinating data shed light on the complicated link between obesity and organ dysfunction,” reported ANI
Or in other words, the authors of the study have proved that obesity could lead to depletion of hair follicle stem cells (HFSCs) through the induction of inflammatory signals, thus effectively blocking hair follicle regeneration and ultimately leading to loss of hair follicles. ANI further reports that “Normally, HFSCs self-renew every hair follicle cycle. This is part of the process that allows our hair to grow back continuously. However, as humans age, HFSCs fail to replenish themselves, leading to fewer HFSCs and therefore hair thinning.”
The report also pointed out that while obese people have a higher risk of androgenic alopecia, it was largely unknown whether obesity accelerates hair thinning, how and the molecular mechanisms of the process were not well understood. The TMDU group involved in the study aimed to address these questions and identified some of these mechanisms.
Hironobu Morinaga, the study’s lead author, said that a high-fat diet accelerates hair thinning by depleting HFSCs that replenish mature cells, especially in older mice. He further says “We compared the gene expression in HFSCs between HFD-fed mice and standard diet-fed mice and traced the fate of those HFSCs after their activation,” adding that the researchers found that HFSCs in HFD-fed obese mice change into the skin surface corneocytes or sebocytes that secrete sebum upon their activation. “Those mice show the faster hair loss and smaller hair follicles along with depletion of HFSCs. Even with HFD feeding in four consecutive days, HFSCs show increased oxidative stress and signs of epidermal differentiation,” said Morinaga.
Emi K. Nishimura, another senior author of the study, points out that the gene expression in HFSCs in high-fat-fed mice indicates the activation of inflammatory cytokine signaling within HFSCs. He said that “The inflammatory signals in HFSCs strikingly repress Sonic hedgehog signaling that plays a crucial role in hair follicle regeneration in HFSCs.”
This study has provided interesting new insights into the specific cellular changes and tissue dysfunction that occur after being fed a high-fat diet or due to genetically induced obesity and it may open the door for future prevention of hair thinning or hair loss.
Source
India.com Can Obesity Lead to Hair Fall? Here’s What The Research Says
https://lifestyle.livemint.com/health/wellness/how-obesity-can-trigger-hair-loss-111633236927596.html
Obesity accelerates hair thinning by stem cell-centric converging mechanisms
https://www.nature.com/articles/s41586-021-03624-x
Source: Story.KISSPR.com
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